The two schools have met only once before, with Oklahoma State a 34-31 winner over Alabama at the 2006 Independence Bowl.
The upcoming series with Alabama is the latest in home-and-home Power-Five scheduling from Oklahoma State, who already has lined up future dates with Arizona State (2022 and 2023), Arkansas (2024 and 2027 and again in 2032 and 2033), Oregon (2025 and 2026) and Nebraska (2034 and 2035).
Looking back and not counting bowl games, OSU has scheduled a number of Power Five opponents in recent years, headlined by a home-and-home series with Georgia (2007 and 2009) and neutral site openers against Mississippi State (2013) and Florida State (2014).
A look at OSU's upcoming non-conference games against Power Five opponents:
Sept. 9 at Arizona State (Tempe)
Sept. 7 vs. Arkansas (Stillwater)
Sept. 6 at Oregon (Eugene)
Sept. 12 vs. Oregon (Stillwater)
Sept. 11 at Arkansas (Fayetteville)
Sept. 23 vs. Alabama (Stillwater)
Sept. 15 at Alabama (Tuscaloosa)
Sept. 18 Arkansas (Stillwater)
Sept. 10 at Arkansas (Fayetteville)
Sept. 16 at Nebraska (Lincoln)
Sept. 15 vs. Nebraska (Stillwater)
Fans can purchase 2021 Cowboy Football season tickets by visiting okstate.com/tickets or by calling or texting 877-ALL-4-OSU. Those who have season tickets have priority renewal opportunities over new season ticket holders, so the most secure way for fans to ensure seat availability in the future is to purchase season tickets now.